%0 Journal Article
%A Galarza, Juan M.
%A Barquera, Rodrigo
%A Álvarez, Ana M. Tito
%A Hernández Zaragoza, Diana I.
%A Sevilla, Gabriela Peralta
%A Tamayo, Andrea
%A Pérez, Mariel
%A Dávila, David
%A Birnberg, Lotty
%A Alonzo, Víctor Acuña
%A Krause, Johannes
%A Grijalva, Marcelo
%+ Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society
%T Genetic diversity of the HLA system in human populations from the Sierra (Andean), Oriente (Amazonian) and Costa (Coastal) regions of Ecuador : 
%U https://hdl.handle.net/21.11116/0000-0007-2E5F-D
%F OTHER: shh1031
%R 10.1016/j.humimm.2018.06.004
%7 2018-06-13
%D 2018
%* Review method: peer-reviewed
%X We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in a total of 1101 Ecuadorian individuals from three regions of the country, the Coastal region, the Andean region, and the Amazonian region, to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent HLA haplotypes with significant linkage disequilibrium in those populations are HLA-A*24∼B*35∼DRB1*04∼DQB1*03:02, A*02∼B*35∼DRB1*04∼DQB1*03:02, A*24∼B*35∼DRB1*14∼DQB1*03:01, A*02∼B*35∼DRB1*14∼DQB1*03:01 and A*02∼B*40:02∼DRB1*04∼DQB1*03:02. The only non-Native American haplotype with frequency >1% shared by all groups was A*29∼B*44∼DRB1*07∼DQB1*02. Admixture estimates obtained by a maximum likelihood method using HLA-B as genetic estimator revealed that the main genetic components for this sample of mixed-ancestry Ecuadorians are Native American (ranging from 52.86% to 63.83%) and European (from 28.95% to 46.54%), while an African genetic component was only apparent in the Coastal region (18.19%). Our findings provide a starting point for the study of population immunogenetics of Ecuadorian populations.
%K HLA, Ecuador, Population immunogenetics, Biological diversity, Mixed ancestry populations, MHC
%J Human Immunology
%V 79
%N 9
%& 639
%P 639 - 650
%I Elsevier
%C New York, N.Y.
%@ 0198-8859