%0 Journal Article
%A Furuzawa-Carballeda, Janette
%A Zuñiga, Joaquín
%A Hernández-Zaragoza, Diana I.
%A Barquera, Rodrigo
%A Marques-García, Eduardo
%A Jiménez-Alvarez, Luis
%A Cruz-Lagunas, Alfredo
%A Ramírez, Gustavo
%A Regino, Nora E.
%A Espinosa-Soto, Ramón
%A Yunis, Edmond J.
%A Romero-Hernández, Fernanda
%A Azamar-Llamas, Daniel
%A Coss-Adame, Enrique
%A Valdovinos, Miguel A.
%A Torres-Landa, Samuel
%A Palacios-Ramírez, Axel
%A Breña, Blanca
%A Alejandro-Medrano, Edgar
%A Hernández-Ávila, Axel
%A Granados, Julio
%A Torres-Villalobos, Gonzalo
%+ Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
%T An original Eurasian haplotype, HLA-DRB1*14:54-DQB1*05:03, influences the susceptibility to idiopathic achalasia : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0007-2BD1-D
%R 10.1371/journal.pone.0201676
%F OTHER: shh1055
%7 2018-08-09
%D 2018
%8 09.08.2018
%* Review method: peer-reviewed
%X Idiopathic achalasia is a relatively infrequent esophageal motor disorder for which major histocompatibility complex (MHC) genes are well-identified risk factors. However, no information about HLA-achalasia susceptibility in Mexicans has previously been reported. We studied a group of 91 patients diagnosed with achalasia and 234 healthy controls with Mexican admixed ancestry. HLA alleles and conserved extended haplotypes were analyzed using high-resolution HLA typing based on Sanger and next-generation sequencing technologies. Admixture estimates were determined using HLA-B and short tandem repeats. Results were analyzed by non-parametric statistical analysis and Bonferroni correction. P-values < 0.05 were considered significant. Patients with achalasia had 56.7% Native American genes, 24.7% European genes, 16.5% African genes and 2.0% Asian genes, which was comparable with the estimates in the controls. Significant increases in the frequencies of alleles DRB1*14:54 and DQB1*05:03 and the extended haplotypes DRB1*14:54-DQB1*05:03 and DRB1*11:01-DQB1*03:01, even after Bonferroni correction (pC<0.05), were found in the achalasia group compared to those in the controls. Concluding, the HLA class II alleles HLA-DRB1*14:54:01 and DQB1*05:03:01 and the extended haplotype are risk factors for achalasia in mixed-ancestry Mexican individuals. These results also suggest that the HLA-DRB1*14:54-DQB1*05:03 haplotype was introduced by admixture with European and/or Asian populations.
%J PLoS One
%V 13
%N 8
%] e0201676
%I Public Library of Science
%C San Francisco, CA
%@ 1932-6203