%0 Journal Article
%A Pacheco-Ubaldo, Hanna
%A Adalid-Sáinz, Carmen
%A Barquera, Rodrigo
%A Clayton, S.
%A Arrieta-Bolaños, Esteban
%A Delgado-Aguirre, Héctor
%A González-Medina, Liliana
%A Hernández-Zaragoza, Diana Iraíz
%A Escareño-Montiel, Néstor
%A Morán-Martínez, Javier
%A Bravo-Acevedo, Alicia
%A Lona-Sánchez, Abraham
%A González-Martínez, Marisela del Rocío
%A Jaramillo-Rodríguez, Yolanda
%A Salgado-Adame, Antonio
%A la Cruz, Federico Juárez-de
%A Zúñiga, Joaquín
%A Yunis, Edmond J.
%A Bekker-Méndez, Carolina
%A Granados, Julio
%+ Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
%T Genetic diversity of HLA system in three populations from Chihuahua, Mexico: Chihuahua City, Ciudad Juárez and rural Chihuahua : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0007-3006-C
%R 10.1016/j.humimm.2019.05.014
%F OTHER: shh2253
%7 2019-06-04
%D 2020
%* Review method: peer-reviewed
%X We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 461 Mexicans from the state of Chihuahua living in Chihuahua city (N = 119), Ciudad Juárez (N = 106) and rural communities (N = 236), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes found in the state of Chihuahua include seven Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in Chihuahua are European (52.12 ± 0.88 by ML; 41.53 of European haplotypes) and Native American (39.51 ± 2.17 by ML; 37.45 of Native American haplotypes), while African genetic component was less apparent (8.36 ± 1.47 by ML; 11.70 of African haplotypes).
%K HLA, Immunogenetics, Population genetics, Chihuahua, Admixture
%J Human Immunology
%V 81
%N 9
%& 485
%P 485 - 488
%I Elsevier
%C New York, N.Y.
%@ 0198-8859