%0 Journal Article
%A Goné-Vázquez, Isis
%A Barquera, Rodrigo
%A Arellano-Prado, Francia Paulina
%A Hernández-Zaragoza, Diana Iraíz
%A Escobedo-Ruíz, Araceli
%A Clayton, Stephen
%A Arrieta-Bolaños, Esteban
%A García-Arias, Víctor Eduardo
%A Rodríguez-López, Marla Estefanía
%A Bravo-Acevedo, Alicia
%A de Sánchez-Fernández, María Guadalupe Jesús
%A Sandoval-Sandoval, Mario J.
%A Gómez-Navarro, Benjamín
%A Zúñiga, Joaquín
%A Yunis, Edmond J.
%A Bekker-Méndez, Carolina
%A Granados, Julio
%+ Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
%T Genetic diversity of HLA system in two populations from Nayarit, Mexico: Tepic and rural Nayarit : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0007-2F87-D
%R 10.1016/j.humimm.2019.06.008
%F OTHER: shh2251
%7 2019-06-11
%D 2020
%* Review method: peer-reviewed
%X We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 161 Mexicans from the state of Nayarit living in Tepic (N = 97) and rural communities (N = 64), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Nayarit include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nayarit are Native American (50.79 ± 5.03 by ML; 42.24 of Native American haplotypes) and European (37.04 ± 6.21 by ML; 35.72 of European haplotypes), while African genetic component is less apparent but relatively high (12.17 ± 2.50 by ML; 13.36 of African haplotypes).
%K HLA, Immunogenetics, Population genetics, Nayarit, Admixture
%J Human Immunology
%V 81
%N 9
%& 499
%P 499 - 501
%I Elsevier
%C New York, N.Y.
%@ 0198-8859