%0 Journal Article
%A Bravo-Acevedo, Alicia
%A Escobedo-Ruíz, Araceli
%A Barquera, Rodrigo
%A Clayton, Stephen
%A García-Arias, Víctor Eduardo
%A Arrieta-Bolaños, Esteban
%A Goné-Vázquez, Isis
%A Hernández-Zaragoza, Diana Iraíz
%A Arellano-Prado, Francia Paulina
%A Rodríguez-López, Marla Estefanía
%A de Sánchez-Fernández, María Guadalupe Jesús
%A Sandoval-Sandoval, Mario J.
%A Gómez-Navarro, Benjamín
%A Zúñiga, Joaquín
%A Yunis, Edmond J.
%A Bekker-Méndez, Carolina
%A Granados, Julio
%+ Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
%T Genetic diversity of HLA system in six populations from Jalisco, Mexico: Guadalajara city, Tlajomulco, Tlaquepaque, Tonalá, Zapopan and rural Jalisco : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0007-2F4B-2
%R 10.1016/j.humimm.2019.05.012
%F OTHER: shh2244
%7 2019-06-04
%D 2020
%* Review method: peer-reviewed
%X We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2046 Mexicans from the state of Jalisco living in the city of Guadalajara (N = 1189), Tlajomulco (N = 30), Tlaquepaque (N = 39), Tonalá (N = 35), Zapopan (N = 168) and rural communities (N = 585), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Jalisco include nine Native American most probable ancestry and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Jalisco are European (48.45 ± 1.18 by ML; 41.66 of European haplotypes) and Native American (44.02 ± 1.24 by ML; 39.86 of Native American haplotypes), while African genetic component is less apparent (7.53 ± 0.30 by ML; 9.62 of African haplotypes).
%K HLA, Immunogenetics, Population genetics, Jalisco, Admixture
%J Human Immunology
%V 81
%N 9
%& 502
%P 502 - 505
%I Elsevier
%C New York, N.Y.
%@ 0198-8859