%0 Journal Article
%A Pontzer, Herman
%A Yamada, Yosuke
%A Sagayama, Hiroyuki
%A Ainslie, Philip N.
%A Andersen, Lene F.
%A Anderson, Liam J.
%A Arab, Lenore
%A Baddou, Issaad
%A Bedu-Addo, Kweku
%A Blaak, Ellen E.
%A Blanc, Stephane
%A Bonomi, Alberto G.
%A Bouten, Carlijn V. C.
%A Bovet, Pascal
%A Buchowski, Maciej S.
%A Butte, Nancy F.
%A Camps, Stefan G.
%A Close, Graeme L.
%A Cooper, Jamie A.
%A Cooper, Richard
%A Das, Sai Krupa
%A Dugas, Lara R.
%A Ekelund, Ulf
%A Entringer, Sonja
%A Forrester, Terrence
%A Fudge, Barry W.
%A Goris, Annelies H
%A Gurven, Michael
%A Hambly, Catherine
%A El Hamdouchi, Asmaa
%A Hoos, Marjije B.
%A Hu, Sumei
%A Joonas, Noorjehan
%A Joosen, Annemiek M.
%A Katzmarzyk, Peter
%A Kempen, Kitty P.
%A Kimura, Misaka
%A Kraus, William E.
%A Kushner, Robert F.
%A Lambert, Estelle V.
%A Leonard, William R.
%A Lessan, Nader
%A Martin, Corby
%A Medin, Anine C.
%A Meijer, Erwin P.
%A Morehen, James C.
%A Morton, James P.
%A Neuhouser, Marian L.
%A Nicklas, Teresa A.
%A Ojiambo, Robert M.
%A Pietiläinen, Kirsi H.
%A Pitsiladis, Yannis P.
%A Plange-Rhule, Jacob
%A Plasqui, Guy
%A Prentice, Ross L.
%A Rabinovich, Roberto A.
%A Racette, Susan B.
%A Raichlen, David A.
%A Ravussin, Eric
%A Reynolds, Rebecca M.
%A Roberts, Susan B.
%A Schuit, Albertine J.
%A Sjödin, Anders M.
%A Stice, Eric
%A Urlacher, Samuel S.
%A Valenti, Giulio
%A Van Etten, Ludo M.
%A Van Mil, Edgar A.
%A Wells, Jonathan C. K.
%A Wilson, George
%A Wood, Brian M.
%A Yanovski, Jack
%A Yoshida, Tsukasa
%A Zhang, Xueying
%A Murphy-Alford, Alexia J.
%A Loechl, Cornelia
%A Luke, Amy H.
%A Rood, Jennifer
%A Schoeller, Dale A.
%A Westerterp, Klaas R.
%A Wong, William W.
%A Speakman, John R.
%+ Department of Human Behavior Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Daily energy expenditure through the human life course : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0009-14C7-0
%R 10.1126/science.abe5017
%7 2021-08-13
%D 2021
%* Review method: peer-reviewed
%X Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.
%J Science
%V 373
%N 6556
%& 808
%P 808 - 812
%I American Association for the Advancement of Science
%C Washington
%@ 0036-80751095-9203