%0 Journal Article
%A Evans, Ben J.
%A Peter, Benjamin
%A Melnick, Don J.
%A Andayani, Noviar
%A Supriatna, Jatna
%A Zhu, Jianlong
%A Tosi, Anthony J.
%+ Genetic Diversity through Space and Time, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Mitonuclear interactions and introgression genomics of macaque monkeys (Macaca) highlight the influence of behaviour on genome evolution : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0009-50B7-E
%R 10.1098/rspb.2021.1756
%7 2021-10-06
%D 2021
%* Review method: peer-reviewed
%X In most macaques, females are philopatric and males migrate from theirnatal ranges, which results in pronounced divergence of mitochondrialgenomes within and among species. We therefore predicted that somenuclear genes would have to acquire compensatory mutations to preservecompatibility with diverged interaction partners from the mitochondria.We additionally expected that these sex-differences would have distinctiveeffects on gene flow in the X and autosomes. Using new genomic datafrom 29 individuals from eight species of Southeast Asian macaque,we identified evidence of natural selection associated with mitonuclear inter-actions, including extreme outliers of interspecies differentiation and metricsof positive selection, low intraspecies polymorphism and atypically longruns of homozygosity associated with nuclear-encoded genes that interactwith mitochondria-encoded genes. In one individual with introgressedmitochondria, we detected a small but significant enrichment of autosomalintrogression blocks from the source species of her mitochondria that con-tained genes which interact with mitochondria-encoded loci. Our analysesalso demonstrate that sex-specific demography sculpts genetic exchangeacross multiple species boundaries. These findings show that behaviourcan have profound but indirect effects on genome evolution by influencinghow interacting components of different genomic compartments (mito-chondria, the autosomes and the sex chromosomes) move through timeand space.
%K cytonuclear incompatibility, interactionnetworks, hybridization, gene flow,natural selection, papionins
%J Proceedings of the Royal Society B: Biological Sciences
%V 288
%N 1960
%] 20211756
%@ 0962-84521471-2954