%0 Journal Article
%A Ojeda-Granados, Claudia
%A Abondio, Paolo
%A Setti, Alice
%A Sarno, Stefania
%A Gnecchi-Ruscone, Guido Alberto
%A González-Orozco, Eduardo
%A De Fanti, Sara
%A Jiménez-Kaufmann, Andres
%A Rangel-Villalobos, Héctor
%A Moreno-Estrada, Andrés
%A Sazzini, Marco
%+ Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society
%T Dietary, Cultural, and Pathogens-Related Selective Pressures Shaped Differential Adaptive Evolution among Native Mexican Populations : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0009-E8F3-F
%R 10.1093/molbev/msab290
%D 2022
%* Review method: peer-reviewed
%X Native American genetic ancestry has been remarkably implicated with increased risk of diverse health issues in several Mexican populations, especially in relation to the dramatic changes in environmental, dietary, and cultural settings they have recently undergone. In particular, the effects of these ecological transitions and Westernization of lifestyles have been investigated so far predominantly on Mestizo individuals. Nevertheless, indigenous groups, rather than admixed Mexicans, have plausibly retained the highest proportions of genetic components shaped by natural selection in response to the ancient milieu experienced by Mexican ancestors during their pre-Columbian evolutionary history. These formerly adaptive variants have the potential to represent the genetic determinants of some biological traits that are peculiar to Mexican people, as well as a reservoir of loci with possible biomedical relevance. To test such a hypothesis, we used genome-wide genotype data to infer the unique adaptive evolution of Native Mexican groups selected as reasonable descendants of the main pre-Columbian Mexican civilizations. A combination of haplotype-based and gene-network analyses enabled us to detect genomic signatures ascribable to polygenic adaptive traits plausibly evolved by the main genetic clusters of Mexican indigenous populations to cope with local environmental and/or cultural conditions. Some of these adaptations were found to play a role in modulating the susceptibility/resistance of these groups to certain pathological conditions, thus providing new evidence that diverse selective pressures have contributed to shape the current biological and disease-risk patterns of present-day Native and Mestizo Mexican populations.
%K adaptive evolution, disease susceptibility, Native Mexican populations
%J Molecular Biology and Evolution 
%V 39
%N 1
%] msab290
%I Oxford University Press
%@ 1537-1719