%0 Journal Article
%A Zeberg, Hugo
%+ Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T The major genetic risk factor for severe COVID-19 is associated with protection against HIV : 
%G eng
%U https://hdl.handle.net/21.11116/0000-000A-03C7-2
%R 10.1073/pnas.2116435119
%7 2022-02-21
%D 2022
%8 21.02.2022
%* Review method: peer-reviewed
%X There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, Nature 600, 472–477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Pääbo, Nature 587, 610–612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an ∼27% lower risk of HIV infection.
%K     COVID-19, HIV, genetics
%J Proceedings of the National Academy of Sciences of the United States of America
%O PNAS
%V 119
%N 9
%] e2116435119 
%I National Academy of Sciences
%C Washington, D.C.
%@ 0027-8424