%0 Journal Article
%A Vagene, Ashild J
%A Honap, Tanvi P.
%A Harkins, Kelly M.
%A Rosenberg, Michael S.
%A Giffin, Karen
%A Cárdenas-Arroyo, Felipe
%A Leguizamón, Laura Paloma
%A Arnett, Judith
%A Buikstra, Jane E.
%A Herbig, Alexander
%A Krause, Johannes
%A Stone, Anne C.
%A Bos, Kirsten I.
%+ Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations : 
%G eng
%U https://hdl.handle.net/21.11116/0000-000A-188F-B
%R 10.1038/s41467-022-28562-8
%7 2022-03-07
%D 2022
%8 07.03.2022
%* Review method: peer-reviewed
%X Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today causes<br>tuberculosis (TB) primarily in pinnipeds, infected human populations living in the coastal<br>areas of Peru prior to European colonization. Skeletal evidence indicates the presence of TB in<br>several pre-colonial South and North American populations with minimal access to marine<br>resources— a scenario incompatible with TB transmission directly from infected pinnipeds or<br>their tissues. In this study, we investigate the causative agent of TB in ten pre-colonial, non-<br>coastal individuals from South America. We reconstruct M. pinnipedii genomes (10- to 15-fold<br>mean coverage) from three contemporaneous individuals from inland Peru and Colombia,<br>demonstrating the widespread dissemination of M. pinnipedii beyond the coast, either through<br>human-to-human and/or animal-mediated routes. Overall, our study suggests that TB<br>transmission in the pre-colonial era Americas involved a more complex transmission pathway<br>than simple pinniped-to-human transfer.
%K Archaeology, Biological anthropology, Genome evolution,  Infectious diseases,  Tuberculosis

%J Nature Communications
%V 13
%] 1195
%@ 2041-1723