%0 Journal Article
%A Yengo, Loic
%A Colleran, Heidi
%+ Department of Human Behavior Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Max Planck Research Group Birth Rites - Cultures of Reproduction, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Constrained human genes under scrutiny : 
%G eng
%U https://hdl.handle.net/21.11116/0000-000A-50F8-4
%R 10.1038/d41586-022-00693-4
%7 2022-03-23
%D 2022
%8 31.03.2022
%* Review method: peer-reviewed
%X Some genes are constrained, which<br>means that damaging variants of them<br>are removed from the population by<br>natural selection.<br>On page 858, Gardner et al.1 investigated<br>the processes underlying this<br>evolutionary process in humans.<br>They report that having a high<br>overall amount of damaging genetic<br>variation in constrained genes is<br>associated with childlessness in men.<br>The association is linked to only 1% of<br>the chance of childlessness between<br>individuals, but to larger effects over<br>many generations in a population.<br>The findings are consistent with the<br>hypothesis that having a greater burden<br>of damaging genetic variation might<br>affect a man’s ability to find a mating<br>partner.
%K Genetics, Evolution, Human behaviour 


%J Nature
%V 603
%& 799
%P 799 - 801
%@ 0028-08361476-4687