%0 Journal Article
%A Yengo, Loic
%A Colleran, Heidi
%+ Department of Human Behavior Ecology and Culture, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Linguistic and Cultural Evolution, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Max Planck Research Group Birth Rites - Cultures of Reproduction, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Constrained human genes under scrutiny : 
%G eng
%U http://hdl.handle.net/21.11116/0000-000A-50F8-4
%R 10.1038/d41586-022-00693-4
%7 2022-03-23
%D 2022
%8 31.03.2022
%* Review method: peer-reviewed
%X Some genes are constrained, which
means that damaging variants of them
are removed from the population by
natural selection.
On page 858, Gardner et al.1 investigated
the processes underlying this
evolutionary process in humans.
They report that having a high
overall amount of damaging genetic
variation in constrained genes is
associated with childlessness in men.
The association is linked to only 1% of
the chance of childlessness between
individuals, but to larger effects over
many generations in a population.
The findings are consistent with the
hypothesis that having a greater burden
of damaging genetic variation might
affect a man’s ability to find a mating
partner.
%K Genetics, Evolution, Human behaviour 


%J Nature
%V 603
%& 799
%P 799 - 801
%@ 0028-08361476-4687