%0 Journal Article
%A Waldman, Shamam
%A Backenroth, Daniel
%A Harney, Éadaoin
%A Flohr, Stefan
%A Neff, Nadia C.
%A Buckley, Gina M.
%A Fridman, Hila
%A Akbari, Ali
%A Rohland, Nadin
%A Mallick, Swapan
%A Nistal, Jorge Cano
%A Yu, Jin
%A Barzilai, Nir
%A Peter, Inge
%A Atzmon, Gil
%A Ostrer, Harry
%A Lencz, Todd
%A Maruvka, Yosef E.
%A Lämmerhirt, Maike
%A Rutgers, Leonard V.
%A Renson, Virginie
%A Prufer, Keith M.
%A Schiffels, Stephan
%A Ringbauer, Harald
%A Sczech, Karin
%A Carmi, Shai
%A Reich, David
%+ Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century : 
%G eng
%U https://hdl.handle.net/21.11116/0000-000A-8310-F
%R 10.1016/j.cell.2022.11.002
%7 2022-12-08
%D 2022
%* Review method: peer-reviewed
%X We report genome-wide data for 33 Ashkenazi Jews (AJ), dated to the 14th century, following a salvage<br>excavation at the medieval Jewish cemetery of Erfurt, Germany. The Erfurt individuals are genetically<br>similar to modern AJ and have substantial Southern European ancestry, but they show more variability<br>in Eastern European-related ancestry than modern AJ. A third of the Erfurt individuals carried the same<br>nearly-AJ-specific mitochondrial haplogroup and eight carried pathogenic variants known to affect AJ<br>today. These observations, together with high levels of runs of homozygosity, suggest that the Erfurt<br>community had already experienced the major reduction in size that affected modern AJ. However, the<br>Erfurt bottleneck was more severe, implying substructure in medieval AJ. Together, our results suggest<br>that the AJ founder event and the acquisition of the main sources of ancestry pre-dated the 14th century<br>and highlight late medieval genetic heterogeneity no longer present in modern AJ.
%K Ashkenazi Jews
ancient DNA
founder event
pathogenic variants
demographic inference
admixture
population structure
mitochondrial DNA
IBD sharing
runs of homozygosity
%J Cell
%V 185
%N 25
%& 4703
%P 4703 - 4716.e16
%I Cell Press
%C Cambridge, Mass.
%@ 0092-8674
%U https://www.biorxiv.org/content/10.1101/2022.05.13.491805v1