%0 Journal Article
%A Childebayeva, Ainash
%A Rohrlach, Adam Ben
%A Barquera Lozano, Rodrigo José
%A Rivollat, M
%A Aron, F
%A Szolek, A
%A Kohlbacher, O
%A Nicklisch, N
%A Alt, KW
%A Gronenborn, D
%A Meller, H
%A Friederich, S
%A Prüfer, Kay
%A Deguilloux, M-F
%A Krause, Johannes
%A Haak, Wolfgang
%+ Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Evolutionary Genomics, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Population genetics and signatures of selection in early Neolithic European farmers : 
%G eng
%U https://hdl.handle.net/21.11116/0000-000A-A1DF-5
%R 10.1093/molbev/msac108
%7 2022-05-17
%D 2022
%* Review method: peer-reviewed
%X Human expansion in the course of the Neolithic transition in western Eurasia has been one of the major topics in ancient DNA (aDNA) research in the last ten years. Multiple studies have shown that the spread of agriculture and animal husbandry from the Near East across Europe was accompanied by large-scale human expansions. Moreover, changes in subsistence and migration associated with the Neolithic transition have been hypothesized to involve genetic adaptation. Here we present high quality genome-wide data from the Linear Pottery Culture (LBK) site Derenburg Meerenstieg II (DER) (N=32 individuals) in Central Germany. Population genetic analyses show that the DER individuals carried predominantly Anatolian Neolithic-like ancestry and a very limited degree of local hunter-gatherer admixture, similar to other early European farmers. Increasing the LBK cohort size to ∼100 individuals allowed us to perform various frequency- and haplotype-based analyses to investigate signatures of selection associated with changes following the adoption of the Neolithic lifestyle. In addition, we developed a new method called AIMLESS (Admixture-informed Maximum-likelihood Estimation for Selection Scans) that allowed us test for selection signatures in an admixture-aware fashion. Focusing on the intersection of results from these selection scans, we identified various loci associated with immune function (JAK1, HLA-DQB1) and metabolism (LMF1, LEPR, SORBS1), as well as skin color (SLC24A5, CD82) and folate synthesis (MTHFR, NBPF3). Our findings shed light on the evolutionary pressures, such as infectious disease and changing diet, that were faced by the early farmers of Western Eurasia. 
%K selection, neolithization, ancient DNA, Linear Pottery culture
%J Molecular Biology and Evolution
%O Mol. Biol. Evol.
%V 39
%N 6
%] msac108
%I Oxford University Press
%C Oxford
%@ 0737-4038