%0 Journal Article
%A Souilmi, Yassine
%A Tobler, Raymond
%A Johar, Angad
%A Williams, Matthew
%A Grey, Shane T.
%A Schmidt, Joshua
%A Teixeira, João C.
%A Rohrlach, Adam Ben
%A Tuke, Jonathan
%A Johnson, Olivia
%A Gower, Graham
%A Turney, Chris
%A Cox, Murray
%A Cooper, Alan
%A Huber, Christian D.
%+ Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
%T Admixture has obscured signals of historical hard sweeps in humans  : 
%G eng
%U https://hdl.handle.net/21.11116/0000-000B-74C1-8
%R 10.1038/s41559-022-01914-9
%7 2022-10-31
%D 2022
%* Review method: peer-reviewed
%X The role of natural selection in shaping biological diversity is an area of <br>intense interest in modern biology. To date, studies of positive selection <br>have primarily relied on genomic datasets from contemporary populations, <br>which are susceptible to confounding factors associated with complex <br>and often unknown aspects of population history. In particular, admixture <br>between diverged populations can distort or hide prior selection events <br>in modern genomes, though this process is not explicitly accounted for in <br>most selection studies despite its apparent ubiquity in humans and other <br>species. Through analyses of ancient and modern human genomes, we show <br>that previously reported Holocene-era admixture has masked more than 50 <br>historic hard sweeps in modern European genomes. Our results imply that <br>this canonical mode of selection has probably b <br><br>een underappreciated in the <br>evolutionary history of humans and suggest that our current understanding <br>of the tempo and mode of selection in natural populations may be <br>inaccurate
%K 
    Molecular evolution ,    Population genetics

%J Nature Ecology & Evolution
%V 6
%& 2003
%P 2003 - 2015
%I Nature Publishing Group
%C London
%@ 2397-334X