%0 Journal Article
%A Forien, Raphaël
%A Ringbauer, Harald
%A Coop, Graham
%+ Haplo Group, Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Demographic inference for spatially heterogeneous populations using long shared haplotypes (advance online) : 
%G eng
%U https://hdl.handle.net/21.11116/0000-000F-229D-A
%R 10.1016/j.tpb.2024.03.002
%7 2023-03-24
%D 2023
%8 24.03.2023
%* Review method: peer-reviewed
%X We introduce a modified spatial Λ-Fleming–Viot process to model the ancestry of individuals in a population occupying a continuous spatial habitat divided into two areas by a sharp discontinuity of the dispersal rate and effective population density. We derive an analytical formula for the expected number of shared haplotype segments between two individuals depending on their sampling locations. This formula involves the transition density of a skew diffusion which appears as a scaling limit of the ancestral lineages of individuals in this model. We then show that this formula can be used to infer the dispersal parameters and the effective population density of both regions, using a composite likelihood approach, and we demonstrate the efficiency of this method on a range of simulated data sets. © 2024 The Authors
%K Population genetics ; Spatial Λ-Fleming–Viot process; Spatial coalescent; Segments of shared haplotypes; 
Skew Brownian motion; Isolation by distance
%J Theoretical Population Biology
%@ 00405809