%0 Journal Article
%A Ostridge, Harrison J.
%A Fontsere, Claudia
%A Lizano, Esther
%A Soto, Daniela C.
%A Schmidt, Joshua M.
%A Saxena, Vrishti
%A Alvarez-Estape, Marina
%A Barratt, Christopher D.
%A Gratton, Paolo
%A Bocksberger, Gaëlle
%A Lester, Jack D.
%A Dieguez, Paula
%A Agbor, Anthony
%A Angedakin, Samuel
%A Assumang, Alfred Kwabena
%A Bailey, Emma
%A Barubiyo, Donatienne
%A Bessone, Mattia
%A Brazzola, Gregory
%A Chancellor, Rebecca
%A Cohen, Heather
%A Coupland, Charlotte
%A Danquah, Emmanuel
%A Deschner, Tobias
%A Dotras, Laia
%A Dupain, Jef
%A Egbe, Villard Ebot
%A Granjon, Anne-Céline
%A Head, Josephine
%A Hedwig, Daniela
%A Hermans, Veerle
%A Hernandez-Aguilar, R. Adriana
%A Jeffery, Kathryn J.
%A Jones, Sorrel
%A Junker, Jessica
%A Kadam, Parag
%A Kaiser, Michael
%A Kalan, Ammie K.
%A Kambere, Mbangi
%A Kienast, Ivonne
%A Kujirakwinja, Deo
%A Langergraber, Kevin E.
%A Lapuente, Juan
%A Larson, Bradley
%A Laudisoit, Anne
%A Lee, Kevin C.
%A Llana, Manuel
%A Maretti, Giovanna
%A Martín, Rumen
%A Meier, Amelia
%A Morgan, David
%A Neil, Emily
%A Nicholl, Sonia
%A Nixon, Stuart
%A Normand, Emmanuelle
%A Orbell, Christopher
%A Ormsby, Lucy Jayne
%A Orume, Robinson
%A Pacheco, Liliana
%A Preece, Jodie
%A Regnaut, Sebastien
%A Robbins, Martha M.
%A Rundus, Aaron
%A Sanz, Crickette
%A Sciaky, Lilah
%A Sommer, Volker
%A Stewart, Fiona A.
%A Tagg, Nikki
%A Tédonzong, Luc Roscelin
%A van Schijndel, Joost
%A Vendras, Elleni
%A Wessling, Erin G.
%A Willie, Jacob
%A Wittig, Roman M.
%A Yuh, Yisa Ginath
%A Yurkiw, Kyle
%A Vigilant, Linda
%A Piel, Alex K.
%A Boesch, Christophe
%A Kühl, Hjalmar S.
%A Dennis, Megan Y.
%A Marques-Bonet, Tomas
%A Arandjelovic, Mimi
%A Andrés, Aida M.
%+ Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Great Ape Evolutionary Ecology and Conservation, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Human Origins, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Department of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Local genetic adaptation to habitat in wild chimpanzees : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0010-E901-6
%R 10.1126/science.adn7954
%7 2025-01-10
%D 2025
%* Review method: peer-reviewed
%X How populations adapt to their environment is a fundamental question in biology. Yet, we know surprisingly little about this process, especially for endangered species, such as nonhuman great apes. Chimpanzees, our closest living relatives, are particularly notable because they inhabit diverse habitats, from rainforest to woodland-savannah. Whether genetic adaptation facilitates such habitat diversity remains unknown, despite it having wide implications for evolutionary biology and conservation. By using newly sequenced exomes from 828 wild chimpanzees (388 postfiltering), we found evidence of fine-scale genetic adaptation to habitat, with signatures of positive selection in forest chimpanzees in the same genes underlying adaptation to malaria in humans. This work demonstrates the power of noninvasive samples to reveal genetic adaptations in endangered populations and highlights the importance of adaptive genetic diversity for chimpanzees.
%K immunodeficiency virus-infection, natural-selection, Pan-Troglodytes, soft sweeps, signatures, evolution, malaria, aids, erythrocytes, association
%J Science
%V 387
%N 6730
%] eadn7954
%I American Association for the Advancement of Science
%C Washington, D.C.
%@ 0036-8075