The genome sequence of a Denisovan individual was generated from a small fragment of a finger bone discovered in Denisova Cave in southern Siberia in 2008.  

Approximately 30-fold coverage of the genome was generated using the Illumina GAIIx sequencing platform.

We provide here the additional high-coverage sequence data which augments the previously published sequence data.

This data is freely available without passwords.

The data represents sequence data generated on the Illumina GAIIx platform and constitutes an average 30-fold coverage of the Denisovan genome. Focussing on the "mappable genome" - the 1.86GB of unique sequence with  clear human-chimpanzee orthology  - we see 99.97% of bases covered at least 3x and 99.51% covered at least 10x.

Contamination with modern human DNA, estimated from both mitochondrial and nuclear genomes, is less than 1%

The Denisova Genome Consortium have chosen to release the raw sequence data and alignments for the additional sequence generated for the Denisova phalanx (Reich et al. Nature. 2010) in the expectation that these data will be a valuable resource for the research community.

In keeping with the Ft. Lauderdale principles, the data are available for use, but users are expected to allow the data producers to make the first presentations and to publish the first paper containing genome-wide analyses of the data. Researchers who use small amounts of the data (eg: for single locus analyses) are not required to request permission. Researchers who have queries about whether they may present or submit Denisova genome data for publication may contact Svante Pääbo.

When using the Denisova genome data is it best to cite our most recent publication:

Reich D, Green RE, Kircher M, Krause J, Patterson N, Durand EY, Viola B, Briggs AW, Stenzel U, Johnson PL, Maricic T, Good JM, Marques-Bonet T, Alkan C, Fu Q, Mallick S, Li H, Meyer M, Eichler EE, Stoneking M, Richards M, Talamo S, Shunkov MV, Derevianko AP, Hublin JJ, Kelso J, Slatkin M, Paabo S: Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature 2010, 468:1053-1060.

The Denisova Genome Consortium have chosen to release the raw sequence data and alignments. 

Provided here are the alignments using BWA to the human (hg19/GRCh37) and chimpanzee (panTro2) genomes.

The sequence and alignment data is made available through:

• local site: http://cdna.eva.mpg.de/denisova/
• Amazon Web Services: The alignments and raw sequence data are available as a public data set via Amazon Web Services (AWS) at http://aws.amazon.com/datasets/2357.