Jump directly to main navigation Jump directly to content Jump to sub navigation

Liver steatosis in ancient and modern humans

Ancient genomes show that the main genetic variant responsible for fatty liver diseases dates back to beyond the split from Neanderthals

Researchers from Würzburg University Hospital (UKW), Homburg University Hospital (UKS), and the Max Planck Institute for Evolutionary Anthropology in Leipzig (MPI-EVA), all in Germany, have analyzed the DNA from a world-wide database of more than 10,000 ancient and modern humans to search for the origin of a mutation in the fatty liver gene PNPLA3 and to explain its strikingly high global presence today.