Genome Engineering and Repair (Stephan Riesenberg)
Welcome to the Genome Engineering and Repair Group at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany!
We are dedicated to exploring the latest innovations in genome engineering and repair. Our focus is on utilizing CRISPR technology to gain a deeper understanding of cellular DNA repair mechanisms and to improve the performance and quality control of CRISPR edits. In close collaboration with Svante Pääbo's research group, we aim to explore the modern phenotype by "neandertalizing" human stem cells. We are also committed to advancing the field through the application of our advancements in clinically relevant cell types for the potential treatment of diseases.
Here are a few selected papers of what we do:
Riesenberg, S., Kanis, P., Macak, D., Wollny, D., Düsterhöft, D., Kowalewski, J., Helmbrecht, N., Maricic, T., & Pääbo, S. (2023). Efficient high-precision homology-directed repair-dependent genome editing by HDRobust. Nature Methods, 20, 1388-1399. |
Open AccessPinson, A., Xing, L., Namba, T., Kalebic, N., Peters, J., Oegema, C. E., Traikov, S., Reppe, K., Riesenberg, S., Maricic, T., Derihaci, R., Wimberger, P., Pääbo, S., & Huttner, W. B. (2022). Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. Science, 377(6611): eabl6422, pp. 1170. |
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Riesenberg, S., Helmbrecht, N., Kanis, P., Maricic, T., & Pääbo, S. (2022). Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage. Nature Communications, 13: 489. |
Open Postdoc Fellowship Opportunity in Genome Engineering:
Contact stephan_riesenberg@[>>> Please remove the text! <<<]eva.mpg.de