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Wednesday, 25th February 2015

15:00Registration opens
17:30Welcome remarks
17:40Michael Lynch: Evolution of the mutation rate
18:10Jean-Jacques Hublin: Timing Human Evolution
20:30Pub crawl (Optional – Please sign up on-site)

Thursday, 26th February 2015

9:30Agnar Helgason: The Y chromosome point mutation rate in humans
10:00Mikkel Schierup: Somatic and germline de novo SNVs and short indels in high coverage Danish trios
10:50David Reich: Genetic evidence for complex speciation of humans and chimpanzees: Has the evidence stood up?
11:20Guy Amster: A sex and age-dependent neutral model for X and autosomes explains polymorphism and divergence patterns in great apes
11:40Mark Stoneking: An overview of mutation rate estimates for human mtDNA
12:00Kateryna Makova: Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA
13:30Michael Stratton: Signatures of mutational processes
14:00Sebastian Zöllner: Genomewide patterns of human germline mutation and signatures of mutational processes
14:20Raheleh Rahbari: Timing, rates and spectra of human germline mutation
14:40Kelley Harris: Recent evolution of the mutation rate and spectrum in Europeans
15:10Poster Session I
15:40Priya Moorjani: The generation time effect on mutation rates in primates
16:00Sarah Lindsay: Modelling the effects of age and mutagen exposure in the mammalian genome
16:20Molly Przeworski: Evaluating the impact of changing generation times on mutation rates
16:50Anne Goriely: The selfish effect of paternal age on mutation rate
17:10Poster Session II
17:40Aylwyn Scally: Evidence for the hominoid slowdown and its potential causes
18:10David Begun: Molecular divergence estimates and the Miocene fossil record
18:30Qiaomei Fu: Calibrating the human mutation rate using an ancient genome
18:50Ilan Gronau: Improving the dates of ancient DNA samples using population-level sequence comparisons
19:10Sessions End
19:30Transport to Restaurant Thüringer Hof by Bus
20:00Dinner at Thüringer Hof

Friday, 27th February 2015

9:00Richard Durbin: Estimation of the ratio of mutation to recombination rate from four population sequences
9:30Pier Francesco Palamara: Inference of human mutation rates using cryptic relatedness in a European population
9:50Mark Lipson: Calibrating the human mutation rate via ancestral recombination density in diploid genomes
10:10Poster Session I + II
11:00Shamil Sunyaev: Genome-wide patterns and properties of de novo mutations in humans
11:30Tobias Warnecke: Germline epigenetics and evolution at hydroxymethylated cytosines
11:50Vladimir Seplyarskiy: Polymerase ζ activity is linked to replication timing in humans: evidence from mutational signatures
12:10Irene Tiemann-Boege: Mutagenesis at recombination hotspots
13:30Discussion and closing remarks


Poster Sessions

Poster NumberPoster SessionTitle
1IArslan et al.: Paternal age effects on offspring mortality and fertility as indicators of the strength of purifying selection in ancient Québec and Krummhörn populations
2IICartwright et al.: DeNovoGear: New methods for estimate mutation rates using related individuals and cells
3IPosth et al.: Interdisciplinary investigation of an archaic hominin femur from the Swabian Jura (South-West Germany)
4IIMathieson et al. Calibrating demographic models with ancient DNA
5IBarbieri et al.: Estimating the TMRCA of the Y chromosome phylogeny with new sequence data from southern Africa
6IIDe Maio et al.: Estimating mutation rates and selection coefficients from great ape genomes using polymorphism-aware phylogenetic models
7IKloosterman et al.: Origin, frequency and functional impact of de novo structural changes in the human genome
8IISkoglund et al.: Mutation rate-based dating of ancient genomes
9ILipatov et al.: Detection of missing variants in 2nd generation DNA sequencing data
10IIJalilian et al.: Analysis of functional variation in 11 cytochrome P450 (CYP) genes: mutation rate is dependent among CYP genes
11ISchiffels et al.: Inferring population sizes and separation times from a large number of samples using rare variants
12IIXue et al.: Constraints on the human Y-chromosomal base substitution mutation rate from ancient DNA sequences
13ISaag et al.: Y-chromosomal mutation rate estimate from ancient DNA sequences
14IIGao et al.: A model for how somatic mutations accrue over time